Acetic Anhydride → N-(hydroxymethyl)acetamide acetate

HRID 129623

Reaktionsgleichung

Reaktionsgleichung von HRID 129623
[C:1]([O:4]C(=O)C)(=[O:3])[CH3:2].[OH:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12]>N1C=CC=CC=1>[C:1]([OH:4])(=[O:3])[CH3:2].[OH:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 69365Formicin

Produkt 1

HCID 86745977N-(hydroxymethyl)acetamide acetateAusbeute 900 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineKatalysator

Versuchsvorschrift

Acetic anhydride (25 g) and pyridine (10 drops) is added to N-(hydroxymethyl)acetamide (9 g, 0.1 mol). The reaction mixture is stirred overnight at room temperature, concentrated in vacuo and chased with xylene to give the title product as an oil (11.9 g, 0.9 mol) which is identified by 1HNMR spectral analysis.

Aufarbeitung

  1. concentrationconcentrated in vacuo and chased with xylene

Quellen und Nachweise

ORD-Eintrag
ord-7c0bd3edec95447594664c9e2887776d
Quelldatensatz
uspto-grants-1995_11
Patentnummer
US05468877

Verknüpfte Notizen

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