Furfuryl Alcohol → 2-(2-Furylmethoxy)-6-(1-Piperazinyl)Pyrazine

HRID 1296620

Reaktionsgleichung

Reaktionsgleichung von HRID 1296620
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:5]=[N:4][CH:3]=1.[O:14]1[CH:18]=[CH:17][CH:16]=[C:15]1[CH2:19][OH:20]>>[O:14]1[CH:18]=[CH:17][CH:16]=[C:15]1[CH2:19][O:20][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[N:7]=1

Komponenten

3

Edukt 2

HCID 7361Furfuryl AlcoholHCID 1079922-Chloro-6-(1-piperazinyl)pyrazine

Produkt 1

HCID 181869452-(2-Furylmethoxy)-6-(1-Piperazinyl)Pyrazine

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

K-t-BuO (1.55 g, 13.8 mmol) was added to a mixture of the product from step 2 above (1.40 g, 7.05 mmol) and 2-furanmethanol (5.3 g, 54 mmol). After being stirred for 7.5 h at 110° C., the mixture was applied onto a bed of silica (16×6 cm). Elution with CHCl3/MeOH (95:5 followed by 90:10) fumished 1.35 g (74%) of the title compound as an oil. HRMS m/z calcd for C13H16N4O2 (M)+ 260.1273, found 260.1276. Anal. (C13H16N4O2) C, H, N.

Aufarbeitung

  1. washElution with CHCl3/MeOH (95:5 followed by 90:10) fumished 1.35 g (74%) of the title compound as an oil

Quellen und Nachweise

ORD-Eintrag
ord-d7cbb22484524911a0566fbf6b3fd4cc
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07247633B2

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