Hydroxylamine → HCID 178453109, Verbindung
Reaktionsgleichung
[C:1]([O:5][C:6](=[O:19])[NH:7][CH2:8][C:9]1([C:17]#[N:18])[C:11]2([CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH2:10]1)([CH3:4])([CH3:3])[CH3:2].[NH2:20][OH:21]>C(O)C>[C:1]([O:5][C:6](=[O:19])[NH:7][CH2:8][C:9]1([C:17](=[NH:18])[NH:20][OH:21])[C:11]2([CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH2:10]1)([CH3:2])([CH3:4])[CH3:3]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of (1-cyano-spiro[2.5]oct-1-ylmethyl)-carbamic acid tert-butyl ester (10.0 g, 37.8 mmol) in ethanol (150 mL) was added 50% aqueous hydroxylamine (12 mL, 189 mmol). The solution was heated to reflux for 14 hours, cooled to room temperature and the solvent removed under reduced vacuum. The residue was partitioned between water (200 mL) and ether (300 mL). An emulsion formed in the ether layer, which was separable. The aqueous layer was extracted with ether (2×300 mL). The combined organic layers were filtered to remove emulsified material. The organic layer was washed with brine (200 mL), dried over sodium sulfate, filtered and evaporated to give 6.1 g (54%) of [1-(N-hydroxycarbamimidoyl)-spiro[2.5]oct-1-ylmethyl]-carbamic acid tert-butyl ester as a white solid: 1H NMR (300 MHz, CDCl3) δ 0.52 (d, J=4.8 Hz, 1H), 0.90 (d, J=4.8 Hz, 1H), 1.4 (m, 1H), 1.43 (s, 9H), 1.3-1.7 (m, 9H), 3.11 (s, 1H), 3.23 (dd, J=5.2, 13.9 Hz, 1H), 3.47 (dd, J=5.2, 13.9 Hz, 1H), 4.68 (s, 2H), 5.12 (s, 1H); MS (APCI) m/z 298 [M+H]+.