Formic Acid → 6-Bromo-4H-imidazo[4,5-b]pyridine

HRID 1297345Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1297345
[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[CH:10](O)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]=[CH:10][NH:8][C:5]2=[N:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 284Formic AcidHCID 6911565-Bromopyridine-2,3-diamine

Produkt 1

HCID 9115786-Bromo-4H-imidazo[4,5-b]pyridine

Versuchsvorschrift

5-Bromo-2,3-diaminopyridine (1.69 g, 8.99 mmole) was taken up in 96% formic acid (50 mL) and heated to reflux. After 18 hr the mixture was cooled to RT and concentrated. The residue was taken up in H2O and the pH was adjusted to 7 with 2.0 M NaOH. The title compound (1.54 g, 87%) was collected as a solid by filtration, washed with H2O, and dried in vacuo: MS (ES) m/e 198/200 (M+H)+.

Aufarbeitung

  1. temperatureheated to reflux
  2. concentrationconcentrated
  3. filtrationThe title compound (1.54 g, 87%) was collected as a solid by filtration
  4. washwashed with H2O
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8cb0bb9ee3904e198d5599c7febb1bb1
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07250424B2

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