Ethylene Glycol → HCID 19370278, Verbindung

Reaktionsgleichung

C(OC([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][O:14][C:15]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH3:16])[CH2:8][CH2:7]1)=O)C.[OH-].[K+].C(O)CO>O>[C:23]1([C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)([O:14][CH2:13][CH2:12][N:9]2[CH2:8][CH2:7][NH:6][CH2:11][CH2:10]2)[CH3:16])[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Komponenten

Versuchsvorschrift

A mixture of 2.6 g (6.8 mmole) of 4-ethoxycarbonyl-1-[2-(1,1-diphenylethoxy)ethyl]piperazine [prepared as described in step (a) above], 3.0 g (5.3 mmole) of potassium hydroxide, 9 ml of water and 30 ml of ethylene glycol was stirred at 160° C. for 2 hours while the water formed was removed by evaporation. The reaction mixture was then poured into ice water, and the mixture was extracted with chloroform, after which it was washed with water. The solvent was then removed by evaporation under reduced pressure, to obtain 1.5 g (yield 71%) of the title compound as an oil.