Ethylamine hydrochloride → 2-(Benzo[1,3]dioxol-5-yloxy)-N-[4-(1-ethylcarbamoyl-1-methyl-ethyl)-benzyl]-nicotinamide

HRID 1297600Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1297600
[CH2:1]([NH-])C.Cl.C(N)C.[O:8]1[C:12]2[CH:13]=[CH:14][C:15]([O:17][C:18]3[N:40]=[CH:39][CH:38]=[CH:37][C:19]=3[C:20]([NH:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]([CH3:36])([C:32](=[O:35])[NH:33][CH3:34])[CH3:31])=[CH:26][CH:25]=3)=[O:21])=[CH:16][C:11]=2[O:10][CH2:9]1>>[O:8]1[C:12]2[CH:13]=[CH:14][C:15]([O:17][C:18]3[N:40]=[CH:39][CH:38]=[CH:37][C:19]=3[C:20]([NH:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]([C:32](=[O:35])[NH:33][CH2:34][CH3:1])([CH3:36])[CH3:31])=[CH:26][CH:25]=3)=[O:21])=[CH:16][C:11]=2[O:10][CH2:9]1

Komponenten

4

Edukt 3

HCID 11198Ethylamine hydrochlorideHCID 187872EthanaminideHCID 101146022-(Benzo[1,3]dioxol-5-yloxy)-N-[4-(1-methyl-1-methylcarbamoyl-ethyl)-benzyl]-nicotinamide

Produkt 1

HCID 102265372-(Benzo[1,3]dioxol-5-yloxy)-N-[4-(1-ethylcarbamoyl-1-methyl-ethyl)-benzyl]-nicotinamide

Versuchsvorschrift

The remaining portion of the tetrahydrofuran solution from Example 5a (10 mL) was converted to the ethyl amide with ethylamine hydrochloride using the same procedure.

Quellen und Nachweise

ORD-Eintrag
ord-5f95505d68174f8797f4db0ccf53eee8
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07250518B2

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