Diisopropylethylamine → 4-ethoxy-6-[(Z)-[4-oxo-2-[[4-(trifluoromethyl)-2-pyridinyl]methylamino]-1,3-thiazol-5-ylidene]methyl]quinoline-3-carbonitrile

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Diisopropylethylamine	HCID 81531	—
Edukt	[4-(Trifluoromethyl)pyridin-2-yl]methanamine	HCID 3682810	—
Edukt	4-Ethoxy-6-[2-methylsulfanyl-4-oxo-4h-thiazol-(5z)-ylidenemethyl]-quinoline-3-carbonitrile	HCID 58585820	—
Produkt	4-ethoxy-6-[(Z)-[4-oxo-2-[[4-(trifluoromethyl)-2-pyridinyl]methylamino]-1,3-thiazol-5-ylidene]methyl]quinoline-3-carbonitrile	HCID 178466946	—

Reaktionsschritte

Similar procedure as described in example 14h was used, starting from 4-ethoxy-6-[2-methylsulfanyl-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile (example 14g), 4-trifluoromethyl-pyridin-2-ylmethylamine and DIEA to give 4-ethoxy-6-[4-oxo-2-[(4-trifluoromethyl-pyridin-2-ylmethyl)-amino]-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile. LC-MS m/e 484 (MH+).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07250515B2
Quelldatensatz	uspto-grants-2007_07
ORD ID	ord-4ada4d80906e4082b00c8fea9b90ec56
Quellennotiz	uspto-grants-2007_07