HRID1297643

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

HCID3682810

(4-(trifluoromethyl)pyridin-2-yl)methanamine

C7H7F3N2

$结构：CCOc1c(C#N)cnc2ccc(/C=C3\SC(SC)=NC3=O)cc12$

HCID58585820

未命名化合物

PRODUCTS

生成物

$结构：CCOc1c(C#N)cnc2ccc(/C=C3\SC(NCc4cc(C(F)(F)F)ccn4)=NC3=O)cc12$

HCID178466946

未命名化合物

PROCEDURE

实验过程

Similar procedure as described in example 14h was used, starting from 4-ethoxy-6-[2-methylsulfanyl-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile (example 14g), 4-trifluoromethyl-pyridin-2-ylmethylamine and DIEA to give 4-ethoxy-6-[4-oxo-2-[(4-trifluoromethyl-pyridin-2-ylmethyl)-amino]-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile. LC-MS m/e 484 (MH+).