Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1298593Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1298593
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>FC(F)(F)c1ccc(P(c2ccc(C(F)(F)F)cc2)c2ccc(C(F)(F)F)cc2)cc1.CC(C)(C)[O-].[K+].COCCOCCOC.COCCOCCOC.COCCOCCOC.COCCOCCOC.COCCOCCOC>Cn1c(=O)c2c(ncn2C)n(C)c1=O.FC(F)(F)c1ccc(N2CCOCC2)cc1.FC(F)(F)c1cccc(N2CCOCC2)c1

Komponenten

8

Edukt 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

Produkt 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholineAusbeute 0 %HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholineAusbeute 0 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23665647Potassium tert-butoxideReagenzHCID 139448Tris(4-trifluoromethylphenyl)phosphineKatalysatorHCID 8150DiglymeLösungsmittel5×

Reaktionsbedingungen

Temperatur
60 °C

Aufarbeitung

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid-Phase beibehalten
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Quellen und Nachweise

ORD-Eintrag
ord-a7e6edebe03d42d0ad8d40bd1f001de6
Quelldatensatz
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Originallink
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