Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1298598Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1298598
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CC(C)(C)c1ccc(C=[CH](c2ccc(C(C)(C)C)cc2)->[Ni](<-[CH](=Cc2ccc(C(C)(C)C)cc2)c2ccc(C(C)(C)C)cc2)<-[CH](=Cc2ccc(C(C)(C)C)cc2)c2ccc(C(C)(C)C)cc2)cc1.COCCOCCOC.FC(F)(F)c1ccc(P(c2ccc(C(F)(F)F)cc2)c2ccc(C(F)(F)F)cc2)cc1.O=P([O-])([O-])[O-].[K+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

Komponenten

9

Edukt 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

Produkt 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholineAusbeute 0 %HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholineAusbeute 0 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 21226062CID 21226062ReagenzHCID 139448Tris(4-trifluoromethylphenyl)phosphineKatalysatorHCID 178440864HCID 178440864, VerbindungKatalysatorHCID 8150DiglymeLösungsmittel5×

Reaktionsbedingungen

Temperatur
60 °C

Aufarbeitung

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid-Phase beibehalten
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Quellen und Nachweise

ORD-Eintrag
ord-f8a50e3a53cb41ee8709fab7db68a64b
Quelldatensatz
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Originallink
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