Morpholine → 4-(4-Trifluoromethylphenyl)morpholine
Reaktionsgleichung
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>c1ccc(P(C23CC4CC(CC(C4)C2)C3)C23CC4CC(CC(C4)C2)C3)c(N2CCCCC2)c1.CC(C)(C)[O-].[K+].COCCOCCOC.COCCOCCOC.COCCOCCOC.COCCOCCOC.COCCOCCOC>Cn1c(=O)c2c(ncn2C)n(C)c1=O.FC(F)(F)c1ccc(N2CCOCC2)cc1.FC(F)(F)c1cccc(N2CCOCC2)c1Komponenten
8
Edukt 2
Produkt 3
Reagenzien, Katalysatoren, Lösungsmittel 3
Reaktionsbedingungen
- Temperatur
- 60 °C
Aufarbeitung
- customThe foil sealing tape was removed from the plate.
- addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
- filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid-Phase beibehalten
- aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.
Quellen und Nachweise
- ORD-Eintrag
- ord-db3e580202f846058c67a2c7706c1a74
- Quelldatensatz
- High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
- Originallink
- Quelle ansehen
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