Morpholine → 4-(4-Trifluoromethylphenyl)morpholine
Reaktionsgleichung
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>C1=[CH]2->[Ni]3(<-[CH](=CCC2)CC1)<-[CH]1=CCC[CH]->3=CCC1.C1CCC(P(CCP(C2CCCCC2)C2CCCCC2)C2CCCCC2)CC1.COCCOCCOC.O=P([O-])([O-])[O-].[K+]>FC(F)(F)c1ccc(N2CCOCC2)cc1Komponenten
9
Edukt 2
Produkt 3
Reagenzien, Katalysatoren, Lösungsmittel 4
Reaktionsbedingungen
- Temperatur
- 60 °C
Aufarbeitung
- customThe foil sealing tape was removed from the plate.
- addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
- filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid-Phase beibehalten
- aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.
Quellen und Nachweise
- ORD-Eintrag
- ord-5b70ef4ddaa5441a9be15d87caa64931
- Quelldatensatz
- High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
- Originallink
- Quelle ansehen
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