Hydrogen Bromide → 16-Bromohexadecanoic acid

HRID 130287

Reaktionsgleichung

Reaktionsgleichung von HRID 130287
O[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18].[BrH:20]>C(O)(=O)C>[Br:20][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18]

Komponenten

4

Edukt 2

HCID 260Hydrogen BromideHCID 1046616-Hydroxyhexadecanoic acid

Produkt 1

HCID 62039716-Bromohexadecanoic acidAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

16-Bromohexadecanoic acid was prepared by refluxing for 48 hrs 5.0 gr (18.35 mmole) of 16-hydroxyhexadecanoic acid in 24 ml of 1:1 v/v mixture of HBr (48% aqueous solution) and glacial acetic acid. Upon cooling, crude product was solidified inside the reaction vessel. It was filtered out and washed with 3×100 ml of cold water. Material was purified by recrystalization from n-hexane, filtered out and dried on high vacuum. 6.1 gr (99% yield) of the desired product were obtained.

Aufarbeitung

  1. custom16-Bromohexadecanoic acid was prepared
  2. temperatureUpon cooling
  3. filtrationIt was filtered out
  4. washwashed with 3×100 ml of cold water
  5. customMaterial was purified by recrystalization from n-hexane
  6. filtrationfiltered out
  7. customdried on high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-626de5c9f4084cca988b41f92ec68041
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07381533B2

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