Bromine → 1-Bromo-2,4-dimethoxy-5-nitrobenzene

HRID 130411

Reaktionsgleichung

Reaktionsgleichung von HRID 130411
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[C:5]([O:12][CH3:13])[CH:4]=1.[Br:14]Br>C(Cl)(Cl)Cl>[Br:14][C:8]1[CH:7]=[C:6]([N+:9]([O-:11])=[O:10])[C:5]([O:12][CH3:13])=[CH:4][C:3]=1[O:2][CH3:1]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 786332,4-Dimethoxy-1-nitrobenzene

Produkt 1

HCID 185436101-Bromo-2,4-dimethoxy-5-nitrobenzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

1,3-Dimethoxy-4-nitrobenzene (5.0 g, 27 mmol) in chloroform (50 ml) at 0° C., was treated with a solution of bromine (1.68 ml, 33 mmol) in chloroform (50 ml). The solution was stirred with warming to room temperature for 4 hours, washed with 10% sodium thiosulfate solution and brine then dried over anhydrous magnesium sulfate and concentrated in vacuo. The crude product was used without further purification (D17). MS (ES+) m/e 262/264 [M+H]+.

Aufarbeitung

  1. washwashed with 10% sodium thiosulfate solution and brine
  2. dry with materialthen dried over anhydrous magnesium sulfate
  3. concentrationconcentrated in vacuo
  4. customThe crude product was used without further purification (D17)

Quellen und Nachweise

ORD-Eintrag
ord-3b86f43fe5bb4cde9afb7354e48b0a98
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07381728B2

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