Stannous Chloride → 8-Fluoro-2-isopropyl-5H-dibenzo[b,e][1,4]diazepin-11-ylamine hydrochloride

HRID 131324

Reaktionsgleichung

Reaktionsgleichung von HRID 131324
Cl.FC1C=CC2NC3C=CC(C)=CC=3C(N)=NC=2C=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([NH:27][C:28]2[CH:35]=[CH:34][C:33]([CH:36]([CH3:38])[CH3:37])=[CH:32][C:29]=2[C:30]#[N:31])=[C:23]([N+:39]([O-])=O)[CH:22]=1.[Sn](Cl)[Cl:43]>>[ClH:43].[F:20][C:21]1[CH:26]=[CH:25][C:24]2[NH:27][C:28]3[CH:35]=[CH:34][C:33]([CH:36]([CH3:38])[CH3:37])=[CH:32][C:29]=3[C:30]([NH2:31])=[N:39][C:23]=2[CH:22]=1

Komponenten

4

Edukt 3

HCID 24479Stannous ChlorideHCID 210934592-(4-Fluoro-2-nitro-phenylamino)-5-isopropyl-benzonitrileHCID 1357977618-Fluoro-2-methyl-5H-dibenzo[b,e][1,4]diazepin-11-ylamine hydrochloride

Produkt 1

HCID 1357977598-Fluoro-2-isopropyl-5H-dibenzo[b,e][1,4]diazepin-11-ylamine hydrochlorideAusbeute 74 %

Versuchsvorschrift

Using a similar procedure as found for 8-fluoro-2-methyl-5H-dibenzo[b,e][1,4]diazepin-11-ylamine hydrochloride, using 2-(4-fluoro-2-nitro-phenylamino)-5-isopropyl-benzonitrile (0.559 g, 1.87 mmol), tin (II) chloride(1.06 g, 5.60 mmol) to obtain the title compound (0.422 g, 1.38 mmol, 74% yield) as a yellow amorphous solid: Mass Spectrum (m/e): 270(M+1).

Quellen und Nachweise

ORD-Eintrag
ord-8d86a4e840054dacb9e74a82457b166c
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07384934B2

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