Pivalaldehyde → 3-[(2,2-Dimethylpropylideneamino)-methyl]-pyrrolidine
Reaktionsgleichung
[NH2:1][CH2:2][CH:3]1[CH2:7][CH2:6][NH:5][CH2:4]1.[CH:8](=O)[C:9]([CH3:12])([CH3:11])[CH3:10]>CO>[CH3:8][C:9]([CH3:12])([CH3:11])[CH:10]=[N:1][CH2:2][CH:3]1[CH2:7][CH2:6][NH:5][CH2:4]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
2.0 g (20 mmol) of 3-aminomethyl-pyrrolidine are initially introduced into 10 ml of methanol, and 1.8 g (22 mmol) of 97% strength pivalaldehyde are added dropwise at room temperature, after which the internal temperature rises to 30° C. The mixture is subsequently stirred for 1 hour and then concentrated, and the residue is distilled through a Vigreux column.
Aufarbeitung
- additionare added dropwise at room temperature
- customrises to 30° C
- concentrationconcentrated
- distillationthe residue is distilled through a Vigreux column
Quellen und Nachweise
- ORD-Eintrag
- ord-2630f868c1ae4906a64306843a19fa7f
- Quelldatensatz
- uspto-grants-1998_03
- Patentnummer
- US05723627
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