3-Methyl-4-methoxybenzenamine → N-(4-Methoxy-3-methylphenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carboxamide

HRID 131665

Reaktionsgleichung

Reaktionsgleichung von HRID 131665
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20](Cl)=[O:21])=[CH:16][CH:15]=1.[CH3:23][O:24][C:25]1[CH:31]=[CH:30][C:28]([NH2:29])=[CH:27][C:26]=1[CH3:32]>>[CH3:23][O:24][C:25]1[CH:31]=[CH:30][C:28]([NH:29][C:20]([C:17]2[CH:18]=[CH:19][C:14]([C:3]3[CH:4]=[C:5]([C:8]4[O:9][C:10]([CH3:13])=[N:11][N:12]=4)[CH:6]=[CH:7][C:2]=3[CH3:1])=[CH:15][CH:16]=2)=[O:21])=[CH:27][C:26]=1[CH3:32]

Komponenten

3

Edukt 2

HCID 672973-Methyl-4-methoxybenzenamineHCID 210788012'-Methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carbonyl chloride

Produkt 1

HCID 10273164N-(4-Methoxy-3-methylphenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carboxamide

Versuchsvorschrift

N-(4-Methoxy-3-methylphenyl)-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carbonyl chloride and 4-methoxy-3-methylaniline using method K. NMR; δH [2H6]—DMSO 10.14,(1H, b), 8.05,(2H, d), 7.90,(1H, dd), 7.57-7.55,(5H, m), 6.92,(1H, d), 3.77,(3H, s), 2.57,(3H, s), 2.33,(3H, s), 2.16,(3H, s). LCMS; retention time 3.53 min, MH+ 414.

Quellen und Nachweise

ORD-Eintrag
ord-d8e42392167f4c1797836b8a19abca60
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07384963B2

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