1-(1,1-dimethylethyl)-N-(phenylmethyl)-4-Piperidinamine → 1-tert-Butylpiperidin-4-amine

HRID 132044

Reaktionsgleichung

Reaktionsgleichung von HRID 132044
C([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]([CH3:18])([CH3:17])[CH3:16])[CH2:11][CH2:10]1)C1C=CC=CC=1>[Pd].CO>[C:15]([N:12]1[CH2:13][CH2:14][CH:9]([NH2:8])[CH2:10][CH2:11]1)([CH3:18])([CH3:16])[CH3:17]

Komponenten

4

Edukt 1

HCID 226479391-(1,1-dimethylethyl)-N-(phenylmethyl)-4-Piperidinamine

Produkt 1

HCID 177504011-tert-Butylpiperidin-4-amineAusbeute 64,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of N-benzyl-1-tert-butylpiperidin-4-amine (1.56 g) and 10% palladium on carbon (2 g) in MeOH (250 ml) was hydrogenated in a Parr shaker at 50 psi for 16 hours. The solution was filtered and the reaction mixture reduced in vacuo, to yield 1-tert-butylpiperidin-4-amine (0.64 g) (LC/MS: Rt 02.31, no [M+H]+).

Aufarbeitung

  1. filtrationThe solution was filtered

Quellen und Nachweise

ORD-Eintrag
ord-75eba7bc9dca434998cf60de6e0f31ca
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07385059B2

Verknüpfte Notizen

Wird geladen…