Di-tert-butyl dicarbonate → Tert-Butyl (2S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethylcarbamate

HRID 132803Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 132803
[NH2:1][CH2:2][C@@H:3]([C@H:5]1[CH2:9][O:8][C:7]([CH3:11])([CH3:10])[O:6]1)[OH:4].[O:12](C(OC(C)(C)C)=O)[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=O>C1COCC1>[CH3:10][C:7]1([CH3:11])[O:6][C@@H:5]([C@@H:3]([OH:4])[CH2:2][NH:1][C:13](=[O:12])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH2:9][O:8]1

Komponenten

4

Edukt 2

HCID 90495Di-tert-butyl dicarbonateHCID 59734745(1S)-2-amino-1-[(4r)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

Produkt 1

HCID 14249481Tert-Butyl (2S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethylcarbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Aminoalcohol 23 was dissolved in THF and BOC2O was added and stirred for several hrs. The solvent was removed and the product purified using silica gel chromatography.

Aufarbeitung

  1. customThe solvent was removed
  2. customthe product purified

Quellen und Nachweise

ORD-Eintrag
ord-6dacd23111d34dacac13d12d18d78972
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07388118B2

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