5-(3-Chloro-propoxy)-1H-indole-2-carboxylic acid ethyl ester → 5-(3-Chloro-propoxy)-1H-indole-2-carboxylic acid
Reaktionsgleichung
OC1C=C2C(=CC=1)N(CC(F)(F)F)C(C(N1CCOCC1)=O)=C2.C([O:26][C:27]([C:29]1[NH:30][C:31]2[C:36]([CH:37]=1)=[CH:35][C:34]([O:38][CH2:39][CH2:40][CH2:41][Cl:42])=[CH:33][CH:32]=2)=[O:28])C>>[Cl:42][CH2:41][CH2:40][CH2:39][O:38][C:34]1[CH:35]=[C:36]2[C:31](=[CH:32][CH:33]=1)[NH:30][C:29]([C:27]([OH:28])=[O:26])=[CH:37]2Komponenten
3
Versuchsvorschrift
In analogy to the procedure described for the synthesis of intermediate 1, step 3, the title compound was synthesized from 5-(3-chloro-propoxy)-1H-indole-2-carboxylic acid ethyl ester (example 4, step 1). The title compound was obtained in 98% yield as white solid. MS (m/e): 252.9 (M−H−, 100%).
Quellen und Nachweise
- ORD-Eintrag
- ord-1f648f46653546e88c7464e7232e9449
- Quelldatensatz