(5-hydroxy-1H-indol-2-yl)-morpholin-4-yl-methanone → {5-[3-(3-Aza-bicyclo[3.1.0]hex-3-yl)-propoxy]-1H-indol-2-yl}-morpholin-4-yl-methanone

HRID 132826

Reaktionsgleichung

Reaktionsgleichung von HRID 132826
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1)=[O:12])=[CH:5]2.[CH:19]12[CH2:24][CH:23]1[CH2:22][N:21]([CH2:25][CH2:26][CH2:27]O)[CH2:20]2>>[CH:19]12[CH2:24][CH:23]1[CH2:22][N:21]([CH2:25][CH2:26][CH2:27][O:1][C:2]1[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1)=[O:12])=[CH:5]3)[CH2:20]2

Komponenten

3

Edukt 2

HCID 44185244(5-hydroxy-1H-indol-2-yl)-morpholin-4-yl-methanoneHCID 675275193-(3-Azabicyclo[3.1.0]hexan-3-yl)propan-1-ol

Produkt 1

HCID 16754253{5-[3-(3-Aza-bicyclo[3.1.0]hex-3-yl)-propoxy]-1H-indol-2-yl}-morpholin-4-yl-methanone

Versuchsvorschrift

In analogy to the procedure described for the synthesis of example 1, step 1, the title compound was synthesized from (5-hydroxy-1H-indol-2-yl)-morpholin-4-yl-methanone (example 5, step 3) and 3-(3-aza-bicyclo[3.1.0]hex-3-yl)-propan-1-ol (example 5, step 2). The title product was obtained in 49% yield as white solid. MS (m/e): 370.5 (MH+, 100%).

Aufarbeitung

  1. customIn analogy to the procedure described for the synthesis of example 1, step 1

Quellen und Nachweise

ORD-Eintrag
ord-3e3303021aa14bd39e263710560930e2
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07388095B2

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