Hydrochloric Acid → HCID 178514823, Verbindung

Isopropylmagnesium chloride (2.0 M in THF) (5.0 mL, 10 mmol) was added to a solution of 3-bromopyridine (1.60 g, 10.0 mmol) in THF (15 mL) under nitrogen atmosphere at room temperature and the mixture was stirred for 1 h. Vinylboronic acid dibutyl ester (3.4 mL) was added to the reaction dropwise and the mixture was stirred at room temperature for 18 h. Water was added and the pH was adjusted to 7 with 1 M hydrochloric acid. The mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried on anhydrous sodium sulfate. The solvent was removed under reduced pressure to give the title compound (1.04 g, 78%).

1. stirringthe mixture was stirred at room temperature for 18 h
2. extractionThe mixture was extracted with ethyl acetate
3. washThe organic layer was washed with brine
4. dry with materialdried on anhydrous sodium sulfate
5. customThe solvent was removed under reduced pressure

ORD-Eintrag

ord-f6c3229880604ca08b2c20172511e4fc

Quelldatensatz

uspto-grants-2008_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07390806B2