[CH:1]1([CH:4]=[C:5]2[N:10]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:9][CH2:8][N:7]3[N:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[N:20]=[C:6]23)[CH2:3][CH2:2]1>[Pd].C(O)C>[C:14]([O:13][C:11]([N:10]1[CH2:9][CH2:8][N:7]2[N:18]=[C:19]([C:21]([F:23])([F:22])[F:24])[N:20]=[C:6]2[CH:5]1[CH2:4][CH:1]1[CH2:2][CH2:3]1)=[O:12])([CH3:17])([CH3:15])[CH3:16]A mixture of 50 mg (0.15 mmol) of tert-butyl 8-(cyclopropylmethylene)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-α]pyrazine-7(8H)-carboxylate and 25 mg of 10% palladium on carbon in 0.5 mL of ethanol was stirred under an atmosphere of hydrogen overnight. The mixture was filtered and the filtrate concentrated to give the title compound.
Wird geladen…