Phosphorus tribromide → 5-(Bromomethyl)-6-chloro-2H-1,3-benzodioxole

HRID 133184Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 133184
[CH2:1]1[O:5][C:4]2[CH:6]=[C:7]([Cl:12])[C:8]([CH2:10]O)=[CH:9][C:3]=2[O:2]1.P(Br)(Br)[Br:14]>C(OCC)C>[Br:14][CH2:10][C:8]1[C:7]([Cl:12])=[CH:6][C:4]2[O:5][CH2:1][O:2][C:3]=2[CH:9]=1

Komponenten

4

Edukt 2

HCID 24614Phosphorus tribromideHCID 7015319(6-Chloro-1,3-benzodioxol-5-yl)methanol

Produkt 1

HCID 191052995-(Bromomethyl)-6-chloro-2H-1,3-benzodioxole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

2.5 g of 6-chloropiperonyl alcohol are dissolved in 80 ml of ethyl ether. The solution is cooled to 0° C. and then 1.9 ml of PBr3 are added. The mixture is stirred at ambient temperature for 18 hours. It is poured onto ice and then extraction is carried out with AcOEt. The organic phase is washed with a saturated NaCl solution. 3.3 g of powder are obtained.

Aufarbeitung

  1. additionIt is poured onto ice
  2. extractionextraction
  3. washThe organic phase is washed with a saturated NaCl solution

Quellen und Nachweise

ORD-Eintrag
ord-c986d68ab36c4f71a5a08261f372926c
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07390818B2

Notizen zur Reaktion

Wird geladen…