N-(Phenylacetyl)-L-alanine → 3-(N'-(Phenylacetyl)-alaninyl)amino-epsilon-caprolactam

HRID 133227

Reaktionsgleichung

Reaktionsgleichung von HRID 133227
[C:1]1([CH2:7][C:8]([NH:10][C@H:11]([C:13]([OH:15])=O)[CH3:12])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:16][CH:17]1[CH2:24][CH2:23][CH2:22][NH:21][C:19](=[O:20])[CH2:18]1>>[C:1]1([CH2:7][C:8]([NH:10][C@H:11]([C:13]([NH:16][CH:17]2[CH2:24][CH2:23][CH2:22][NH:21][C:19](=[O:20])[CH2:18]2)=[O:15])[CH3:12])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

3

Edukt 2

HCID 7004640N-(Phenylacetyl)-L-alanineHCID 215841384-Aminoazepan-2-one

Produkt 1

HCID 102150973-(N'-(Phenylacetyl)-alaninyl)amino-epsilon-caprolactam

Versuchsvorschrift

Following General Procedure B above using N-(phenylacetyl)-L-alanine (Example A) and 3-aminocaprolactam (Sigma), the title compound was prepared as a solid having a melting point of 200-202° C. The reaction was monitored by tlc on silica gel (Rf=0.30 in 1:9 methanol/dichloromethane).

Quellen und Nachweise

ORD-Eintrag
ord-987c3041d8ff4f4fa979fdca053d055a
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07390801B2

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