Pyridine → Isobutyl 2-bromopropionate

HRID 133308

Reaktionsgleichung

Reaktionsgleichung von HRID 133308
[CH2:1]([OH:5])[CH:2]([CH3:4])[CH3:3].N1C=CC=CC=1.[Br:12][CH:13]([CH3:17])[C:14](Br)=[O:15]>C(OCC)C>[Br:12][CH:13]([CH3:17])[C:14]([O:5][CH2:1][CH:2]([CH3:4])[CH3:3])=[O:15]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 6560IsobutanolHCID 79047Propanoyl bromide, 2-bromo-

Produkt 1

HCID 522337Isobutyl 2-bromopropionate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

To a mixture of iso-butanol and 1.0 equivalent of pyridine in dry diethyl ether was added dropwise 1.3 equivalents of 2-bromopropionyl bromide at 0° C. After stirring at room temperature for 16 hours, the reaction was diluted with diethyl ether, washed with 1N HCl, water, aqueous NaHCO3, brine and dried over magnesium sulfate or sodium sulfate. Removal of the solvents at reduced pressure gave the title compound as a clear oil.

Aufarbeitung

  1. washwashed with 1N HCl, water, aqueous NaHCO3, brine
  2. dry with materialdried over magnesium sulfate or sodium sulfate
  3. customRemoval of the solvents at reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bf0296674c8a4d2b99889b4a6245a2a7
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07390801B2

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