Triethylamine → 3,5-Dichlorobenzyl methanesulfonate

HRID 133348

Reaktionsgleichung

Reaktionsgleichung von HRID 133348
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[CH2:5][OH:6].[CH3:11][S:12](Cl)(=[O:14])=[O:13].C(N(CC)CC)C>ClCCl>[CH3:11][S:12]([O:6][CH2:5][C:4]1[CH:3]=[C:2]([Cl:1])[CH:9]=[C:8]([Cl:10])[CH:7]=1)(=[O:14])=[O:13]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 432363,5-Dichlorobenzylic alcohol

Produkt 1

HCID 224922533,5-Dichlorobenzyl methanesulfonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a solution of 3.5 g of 3,5-dichlorobenzyl alcohol (Aldrich) in 75 mL of dichloromethane at 0° C. was added 1.8 mL of methane sulfonylchloride followed by 3.5 mL of triethylamine added dropwise. After 2 hours the solution was diluted to 150 mL with dichloromethane, washed with 3N HCl, saturated aqueous NaHCO3 dried with Na2SO4 and the solvents removed to yield the desired 3,5-dichlorobenzyl methanesulfonate as a yellow oil that was used without purification.

Aufarbeitung

  1. additionadded dropwise
  2. washwashed with 3N HCl, saturated aqueous NaHCO3
  3. dry with materialdried with Na2SO4
  4. customthe solvents removed

Quellen und Nachweise

ORD-Eintrag
ord-82ce7505cc384f4c9ec0c6e9a0874efc
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07390801B2

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