L-Alanine ethyl ester → N-[(2-phenyl)-2-fluoroacetyl]alanine Ethyl Ester
Reaktionsgleichung
[F:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([OH:5])=O.[CH2:12]([O:14][C:15](=[O:19])[C@H:16]([CH3:18])[NH2:17])[CH3:13]>>[CH2:12]([O:14][C:15](=[O:19])[C@H:16]([CH3:18])[NH:17][C:3](=[O:5])[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[F:1])[CH3:13]Komponenten
3
Versuchsvorschrift
Following General Procedure BF above, and using α-fluorophenyl acetic acid (Aldrich) and alanine ethyl ester (Aldrich), the title compound was prepared. The reaction was monitored by tlc on silica gel (Rf=0.75 in 1:1 EtOAc:hexane) and purification was by chromatography on silica gel using 1:2 ethyl acetate/hexanes as the eluent.
Aufarbeitung
- customThe reaction was monitored by tlc on silica gel (Rf=0.75 in 1:1 EtOAc:hexane) and purification
Quellen und Nachweise
- ORD-Eintrag
- ord-8518db2c4b76423687970c4395dbf419