Dimethylformamide → 4-Bromo-5-(4-methanesulfonyl-phenoxy)-2-nitro-phenylamine

HRID 13341

Reaktionsgleichung

Reaktionsgleichung von HRID 13341
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)(=[O:4])=[O:3].C(=O)([O-])[O-].[K+].[K+].CN(C)C=O.[Br:23][C:24]1[C:29](F)=[CH:28][C:27]([NH2:31])=[C:26]([N+:32]([O-:34])=[O:33])[CH:25]=1>O>[Br:23][C:24]1[C:29]([O:11][C:8]2[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:6][CH:7]=2)=[CH:28][C:27]([NH2:31])=[C:26]([N+:32]([O-:34])=[O:33])[CH:25]=1

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 1233504-(Methylsulfonyl)phenolHCID 219119284-Bromo-5-fluoro-2-nitroaniline

Produkt 1

HCID 231452284-Bromo-5-(4-methanesulfonyl-phenoxy)-2-nitro-phenylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

5.2 g of 4-methanesulfonyl-phenol and 5.7 g of potassium carbonate were added in order to an N,N-dimethylformamide (50 ml) solution of 6.4 g of 4-bromo-5-fluoro-2-nitrophenylamine, and the reaction liquid was stirred at 120° C. for 3 hours. 200 ml of water was added to the reaction liquid, and the precipitated solid was taken out through filtration and dried to obtain the entitled compound as a brown solid.

Aufarbeitung

  1. customthe reaction liquid
  2. filtrationthe precipitated solid was taken out through filtration
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-2db425b5a31749ebb865df94ca6c54f9
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728025B2

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