Diethylamine → (2-Aminothiophen-3-YL)(4-fluorophenyl)methanone

HRID 133520

Reaktionsgleichung

Reaktionsgleichung von HRID 133520
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:12])[CH2:9][C:10]#[N:11])=[CH:4][CH:3]=1.[S:13]1CC(O)S[CH2:15][CH:14]1O.C(NCC)C>C(O)C>[NH2:11][C:10]1[S:13][CH:14]=[CH:15][C:9]=1[C:8]([C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)=[O:12]

Komponenten

5

Edukt 3

HCID 8021DiethylamineHCID 983301,4-Dithiane-2,5-diolHCID 2783172p-Fluorobenzoylacetonitrile

Produkt 1

HCID 11074943(2-Aminothiophen-3-YL)(4-fluorophenyl)methanoneAusbeute 86,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

Following a procedure described in J. Med. Chem. 2002, 45, 382-389; 0.44 g (2.7 mmol) 3-(4-fluoro-phenyl)-3-oxo-propionitrile (the preparation of which is described in example 17), 0.33 g (2.15 mmol) [1,4]dithiane-2,5-diol, 0.16 ml (2.15 mmol) diethyl-amine and 5 ml ethanol were charged in a sealed tube. The reaction mixture was heated at 50° C. for 6 h. The tube was then placed in a fridge (about 4° C.) for the night, and the product was collected by filtration and dried under vacuum to afford 0.41 g (69%) (2-amino-thiophen-3-yl)-(4-fluoro-phenyl)-methanone as a light brown crystals.

Aufarbeitung

  1. additionwere charged in a sealed tube
  2. customwas then placed in a fridge (about 4° C.) for the night
  3. filtrationthe product was collected by filtration
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-42962bf534a9470cb3f05f45307509c3
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07390903B2

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