2,4-Difluorobenzonitrile → 4-(2-Cyano-5-fluoro-phenoxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyrazin-2-yl-1H-benzimidazole

HRID 13380

Reaktionsgleichung

Reaktionsgleichung von HRID 13380
[C:1]([C:3]1[CH:36]=[CH:35][CH:34]=[C:33](F)[C:4]=1[O:5][C:6]1[C:14]2[N:13]=[C:12]([C:15]3[CH:20]=[N:19][CH:18]=[CH:17][N:16]=3)[NH:11][C:10]=2[CH:9]=[C:8]([O:21][C:22]2[CH:23]=[N:24][C:25]([S:28]([CH2:31][CH3:32])(=[O:30])=[O:29])=[CH:26][CH:27]=2)[CH:7]=1)#[N:2].[F:38]C1C=C(F)C=CC=1C#N>>[C:1]([C:3]1[CH:36]=[CH:35][C:34]([F:38])=[CH:33][C:4]=1[O:5][C:6]1[C:14]2[N:13]=[C:12]([C:15]3[CH:20]=[N:19][CH:18]=[CH:17][N:16]=3)[NH:11][C:10]=2[CH:9]=[C:8]([O:21][C:22]2[CH:23]=[N:24][C:25]([S:28]([CH2:31][CH3:32])(=[O:30])=[O:29])=[CH:26][CH:27]=2)[CH:7]=1)#[N:2]

Komponenten

3

Edukt 2

HCID 775452,4-DifluorobenzonitrileHCID 113182844-(2-Cyano-6-fluoro-phenoxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyrazin-2-yl-1H-benzimidazole

Produkt 1

HCID 231457744-(2-Cyano-5-fluoro-phenoxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyrazin-2-yl-1H-benzimidazole

Versuchsvorschrift

The entitled compound was obtained in the same method as in Example 438 (step 2) or in accordance with the method or by combining it with an ordinary method but using 4-hydroxy-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyrazin-2-yl-1H-benzimidazole obtained in Example 442 and 2,4-difluoro-benzonitrile.

Aufarbeitung

  1. customThe entitled compound was obtained in the same method as in Example 438 (step 2) or in accordance with the method

Quellen und Nachweise

ORD-Eintrag
ord-66a93e76712942c3813a3be8630cacbb
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728025B2

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