Water → [1-(4-Isothiocyanato-phenyl)-piperidin-4-yl]-dimethyl-amine

HRID 1348564

Reaktionsgleichung

Reaktionsgleichung von HRID 1348564
[CH3:1][N:2]([CH3:18])[CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)[CH2:5][CH2:4]1.[C:19](C1NC=CN=1)(C1NC=CN=1)=[S:20].O>CN(C=O)C>[N:15]([C:12]1[CH:13]=[CH:14][C:9]([N:6]2[CH2:7][CH2:8][CH:3]([N:2]([CH3:18])[CH3:1])[CH2:4][CH2:5]2)=[CH:10][CH:11]=1)=[C:19]=[S:20]

Komponenten

5

Edukt 3

HCID 962WaterHCID 11086151N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amineHCID 11412697Thiocarbonyl diimidazole

Produkt 1

HCID 21091577[1-(4-Isothiocyanato-phenyl)-piperidin-4-yl]-dimethyl-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Dimethyl-[1-(4-nitro-phenyl)-piperidin-4-yl]-amine (Example 2, 1.1 g, 5.0 mmol) was dissolved in DMF (5 mL). To the stirred solution, thiocarbonyl diimidazole (Aldrich, 1.18 g, 90%, 6 mmol) was added and the solution was stirred at room temperature for 80 minutes. The mixture was poured into water and extracted with diethyl ether. The extract was dried with sodium sulfate and concentrated to give a pale yellow solid. 1.12 g, 85%. MS (m+H)+: 262.

Aufarbeitung

  1. extractionextracted with diethyl ether
  2. dry with materialThe extract was dried with sodium sulfate
  3. concentrationconcentrated
  4. customto give a pale yellow solid

Quellen und Nachweise

ORD-Eintrag
ord-96af6633f0ff44f3afb9eaf504ffa333
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07211576B2

Verknüpfte Notizen

Wird geladen…