Sodium Methoxide → 3-[3-(4-Fluorophenyl)(1h-indazol-5-yl)]-5-(pyrrolidinylmethyl)-1h-1,2,4-triazole

HRID 1349838

Reaktionsgleichung

Reaktionsgleichung von HRID 1349838
Cl.C(O[C:5]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][N:11]=[C:10]2[C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1)=[NH:6])C.NNC([CH:27]1[CH2:31][CH2:30][CH2:29][NH:28]1)=O.C[O-].[Na+].O=[C:36]1[CH:40]=C[N:38]=[N:37]1>CO>[F:22][C:19]1[CH:18]=[CH:17][C:16]([C:10]2[C:9]3[C:13](=[CH:14][CH:15]=[C:7]([C:5]4[N:6]=[C:36]([CH2:40][N:28]5[CH2:27][CH2:31][CH2:30][CH2:29]5)[NH:37][N:38]=4)[CH:8]=3)[NH:12][N:11]=2)=[CH:21][CH:20]=1

Komponenten

6

Edukt 4

HCID 10942334Sodium MethoxideHCID 11513733PyrazoloneHCID 14045869Pyrrolidine-2-carbohydrazideHCID 22479739ethoxy[3-(4fluorophenyl)(1H-indazol-5-yl)]methanimine hydrochloride

Produkt 1

HCID 100215353-[3-(4-Fluorophenyl)(1h-indazol-5-yl)]-5-(pyrrolidinylmethyl)-1h-1,2,4-triazoleAusbeute 5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

A suspension of ethoxy[3-(4-fluorophenyl)(1H-indazol-5-yl)]methanimine hydrochloride (0.500 g, 1.56 mmol) and N-aminopyrrolidin-2-ylcarboxamide (0.606 g, 4.69 mmol) in 4 mL of anhydrous methanol was prepared. An excess of a commercial solution of sodium methoxide in methanol (0.727 mL, 4.37 M) was added. After 2 h, the temperature was raised to reflux and was maintained for 48 hours. The analysis of the mixture showed the formation of the corresponding oxodiazole occurring as a side reaction. The reaction was then quenched with water, the pH adjusted to neutral and the crude product extracted with ethyl acetate. The title compound was purified by preparative HPLC (0.030 g, 5% yield): 1H NMR (CD3OD) δ 8.69 (t, 1H), 8.10–8.02 (m, 3H), 7.68 (d, 1H), 7.05 (t, 2H), 4.52 (t, 1H), 3.17 (m, 2H), 2.39–1.99 (m, 4H), 2.37 (s, 6H), 2.30 (s, 2H), 1.12 (s, 9H); ES-MS (m/z) 349 [M+H]+.

Aufarbeitung

  1. customwas prepared
  2. temperaturethe temperature was raised
  3. temperatureto reflux
  4. temperaturewas maintained for 48 hours
  5. customas a side reaction
  6. customThe reaction was then quenched with water
  7. extractionextracted with ethyl acetate
  8. customThe title compound was purified by preparative HPLC (0.030 g, 5% yield)

Quellen und Nachweise

ORD-Eintrag
ord-e44ccc2da617463d9ac97ffe695335d1
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07211594B2

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