(+)-Nootkatone → beta-Nootkatol

HRID 1349933

Reaktionsgleichung

Reaktionsgleichung von HRID 1349933
[CH3:1][C@H:2]1[C@:8]2([CH3:16])[CH2:9][C@H:10]([C:13]([CH3:15])=[CH2:14])[CH2:11][CH2:12][C:7]2=[CH:6][C:4](=[O:5])[CH2:3]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>CCOCC>[CH3:1][C@H:2]1[C@:8]2([CH3:16])[CH2:9][C@H:10]([C:13]([CH3:15])=[CH2:14])[CH2:11][CH2:12][C:7]2=[CH:6][C@@H:4]([OH:5])[CH2:3]1

Komponenten

4

Edukt 2

HCID 1268142(+)-NootkatoneHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 182645beta-Nootkatol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

β-Nootkatol was prepared by reduction of 190 mg nootkatone (Fluka) with 20 mg of LiAlH4 in in 5 mL dry ether (diethyl-ether) (Shoji et al., 1984). After stirring the grey suspension for one night, the reaction was stopped by careful addition of Na2SO4.10H2O. The mlxture was stirred for an additional 30 minutes, and dried by the addition of MgSO4. The solids were filtered off and the ether was washed with distilled water. After drying and evaporation of the solvent, 140 mg of a crude oil was obtained that besides β-nootkatol contained 4% of α-nootkatol, EIMS (70 eV) m/z: 220 [M]+ (33), 177 (77), 161 (40), 145 (52), 131 (77), 119 (100), 109 (41), 107 (50), 105 (59), 95 (46), 93 (60), 91 (43), 81 (45), 79 (80), 77 (64), 69 (47), 67 (52), 55 (58), 43 (55), 41 (94), 39 (54). After flash chromatography of 50 mg from this crude oil on silica with ether-pentane (2:1), fractions devoid of any trace of α:-nootkatol were pooled yielding 3.6 mg of β-nootkatol. 1H NMR (200 MHz, C6D6) δ 0.83 (d, 3H, J=3 Hz), δ 0.95 (s, 3H), δ 0.96–1.47 (m, 7H), δ 1.75 (m, 3H), δ 1.93 (dt, 1H, J=12.7 and 2.7 Hz), δ 2.07 (m, 1H), δ 2.20–2.33 (m, 2H), δ 4.19–4.26 (m, 1H), δ 4.88 (br s, 2H), 5.44 (br d, 1H). 13C NMR (100 MHz, DEPT, CDCl3) δ 15.7 (q), δ 18.4 (q), δ 21.1 (q), δ 32.8 (t), δ 33.4 (t), δ 37.8 (t), δ 38.5 (s), δ 39.8 (d), δ 41.3 (d), δ 45.1 (t), δ 68.1 (d), δ 109.2 (t), 125.9 (d), δ 144.9 (s), δ 150.2 (s). EIMS (70 eV) m/z: 220 [M]+ (56), 177 (100), 145 (31), 135 (51), 131 (43), 123 (38), 121 (91), 119 (81), 109 (42), 107 (66), 105 (62), 95 (49), 93 (69), 91 (87), 81 (39), 79 (60), 77 (56), 69 (45), 67 (51) 55 (62), 53 (42), (52), 41 (100), 39 (55).

Aufarbeitung

  1. stirringThe mlxture was stirred for an additional 30 minutes
  2. dry with materialdried by the addition of MgSO4
  3. filtrationThe solids were filtered off
  4. washthe ether was washed with distilled water
  5. customAfter drying
  6. customevaporation of the solvent
  7. custom140 mg of a crude oil was obtained that besides β-nootkatol

Quellen und Nachweise

ORD-Eintrag
ord-d1d264d986404b5e87b15ab8dc266b9e
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07214507B2

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