Water → 1-Carbomethoxy-2-benzylamino-3,4-dihydronaphthalene

HRID 1350192

Reaktionsgleichung

Reaktionsgleichung von HRID 1350192
[C:1]([CH:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][C:6]1=O)([O:3][CH3:4])=[O:2].C(O)(=O)C(C)C.[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.O>C1(C)C=CC=CC=1>[C:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][C:6]=1[NH:29][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([O:3][CH3:4])=[O:2]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6590Isobutyric AcidHCID 7504BenzylamineHCID 5991311-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-2-oxo-, methyl ester

Produkt 1

HCID 210946731-Carbomethoxy-2-benzylamino-3,4-dihydronaphthaleneAusbeute 102,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of 1-carbomethoxy-2-oxo-1,2,3,4-tetrahydronaphthalene (10.2 g) and isobutyric acid (4.84 g) in toluene (150 mL) stirring at room temperature under argon, was added benzylamine (5.35 g). The resulting mixture was heated to reflux for 2 h with water removal using a Dean-Stark trap. The solvent was then evaporated under vacuum to provide the title compound (15 g) as a yellow gum.

Aufarbeitung

  1. temperatureThe resulting mixture was heated
  2. customThe solvent was then evaporated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-e1562b7a1b0342efa5869dca9cb48120
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07214704B2

Verknüpfte Notizen

Wird geladen…