HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(1-Naphthyl)piperazine → 2-{2-[4-(1-Naphthyl)-1-piperazinyl]ethyl}-1H-isoindole-1,3(2H)-dione
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(1-Naphthyl)piperazine | HCID 1342 | — |
| Edukt | 1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- | HCID 11325 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 2-{2-[4-(1-Naphthyl)-1-piperazinyl]ethyl}-1H-isoindole-1,3(2H)-dione | HCID 21096932 | — |
Reaktionsbedingungen
| Temperatur | 90 °C |
|---|
Reaktionsschritte
A suspension of 1.17 g (5.52 mmol) of 1-(1-naphthyl)piperazine (Tetrahedron Letters, 1998, 39(15), 2219–2222), 0.99 g (7.15 mol) of potassium carbonate and 1.68 g (6.62 mmol) of 2-(2-bromoethyl)-1H-isoindole-1,3(2H)-dione in 15 ml of N,N-dimethylformamide is heated at 90° C. for 2 hours.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07214798B2 |
| Quelldatensatz | uspto-grants-2007_05 |
| ORD ID | ord-7fd467fb8a3143529674a2598697ba10 |
| Quellennotiz | uspto-grants-2007_05 |