Dimethylformamide → 2-[(R)-1-(3-Toluoyloxy-2-oxo-propylamino)-2-methyl-propyl]-3-benzyl-7-chloro-3H-quinazolin-4-one

HRID 1350636Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1350636
[NH2:1][C@@H:2]([C:6]1[N:15]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:14](=[O:23])[C:13]2[C:8](=[CH:9][C:10]([Cl:24])=[CH:11][CH:12]=2)[N:7]=1)[CH:3]([CH3:5])[CH3:4].CCN([CH:31]([CH3:33])[CH3:32])C(C)C.[C:34]1(C)[C:35]([C:40]([O:42]CC(=O)CBr)=[O:41])=[CH:36]C=C[CH:39]=1.[C:49](Cl)(=[O:56])[C:50]1C=CC=CC=1.[CH3:58]N(C=O)C>>[C:31]1([CH3:32])[CH:33]=[CH:39][CH:34]=[C:35]([C:40]([O:42][N:1]([CH2:58][C:49](=[O:56])[CH3:50])[C@@H:2]([C:6]2[N:15]([CH2:16][C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:14](=[O:23])[C:13]3[C:8](=[CH:9][C:10]([Cl:24])=[CH:11][CH:12]=3)[N:7]=2)[CH:3]([CH3:5])[CH3:4])=[O:41])[CH:36]=1

Komponenten

6

Edukt 5

HCID 6228DimethylformamideHCID 7412Benzoyl chlorideHCID 81531DiisopropylethylamineHCID 21015281(R)-2-(1-amino-2-methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-oneHCID 865918921-Toluoyloxy-3-bromopropan-2-one

Produkt 1

HCID 210969932-[(R)-1-(3-Toluoyloxy-2-oxo-propylamino)-2-methyl-propyl]-3-benzyl-7-chloro-3H-quinazolin-4-one

Versuchsvorschrift

To 2-((R)-1-amino-2-methyl-propyl)-3-benzyl-7-chloro-3H-quinazolin-4-one (1.0 g, 2.9 mMol) in DMF (10 mL) was added DIEA (0.6 mL, 3.4 mMol) and 1-toluoyloxy-3-bromopropan-2-one (1.0 g, 3.7 mMol) (Prepared using the procedure of F. C. Hartman, Biochemistry, 9, 1776 (1970) except substituting toluoyl chloride for benzoyl chloride.) The reaction was stirred at RT for 18 h, concentrated under vacuum, taken up in EtOAc, washed with 1 N Na2CO3, dried (Na2SO4) and evaporated to dryness. The product was converted to its hydrochloride salt by treating with 4 N HCl in dioxane (20 mL) and concentration under vacuum. Trituration with (1:1) Et2O/pet. ether, filtration and drying under vacuum left the title compound (1.87 g, 100%, 88% pure) as a beige solid: MS (ES) m/e 532.2 (M+H)+.

Aufarbeitung

  1. customPrepared
  2. concentrationconcentrated under vacuum
  3. washwashed with 1 N Na2CO3
  4. dry with materialdried (Na2SO4)
  5. customevaporated to dryness
  6. additionby treating with 4 N HCl in dioxane (20 mL) and concentration under vacuum
  7. filtrationTrituration with (1:1) Et2O/pet. ether, filtration
  8. customdrying under vacuum
  9. waitleft the title compound (1.87 g, 100%, 88% pure) as a beige solid

Quellen und Nachweise

ORD-Eintrag
ord-37b1174dc9f04dc3b02954e2b345af00
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07214800B2

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