N,N-dimethyl-5-nitropyridin-2-amine → N2,N2-dimethylpyridine-2,5-diamine

HRID 13507

Reaktionsgleichung

Reaktionsgleichung von HRID 13507
[CH3:1][N:2]([CH3:12])[C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][N:4]=1>[Pd].C(O)C>[CH3:1][N:2]([CH3:12])[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][N:4]=1

Komponenten

4

Edukt 1

HCID 75707N,N-dimethyl-5-nitropyridin-2-amine

Produkt 1

HCID 78642N2,N2-dimethylpyridine-2,5-diamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2-(dimethylamino)-5-nitropyridine (1 eq) and 5% palladium on carbon (0.3 eq) in ethanol was stirred at room temperature and flushed with nitrogen. The reaction vessel was evacuated and purged with hydrogen three times. The reaction mixture was left under an atmosphere of hydrogen overnight. Nitrogen was flushed through the reaction and then the reaction was filtered through a celite pad. The celite pad was washed with excess ethanol before the solvent was removed by evaporation under reduced pressure to afford 2-(dimethylamino)-5-aminopyridine.

Aufarbeitung

  1. customflushed with nitrogen
  2. customThe reaction vessel was evacuated
  3. custompurged with hydrogen three times
  4. customNitrogen was flushed through the reaction
  5. filtrationthe reaction was filtered through a celite pad
  6. washThe celite pad was washed with excess ethanol before the solvent
  7. customwas removed by evaporation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b3951463aaae402abfa19be9984785d4
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728010B2

Verknüpfte Notizen

Wird geladen…