Hydrogen chloride-ethyl acetate → [2-(4-Fluoro-3-methoxyphenyl)ethyl]methylamine hydrochloride

HRID 1351263Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1351263
C(O[C:6](=O)[N:7]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[C:13]([O:18][CH3:19])[CH:12]=1)C)(C)(C)C.[ClH:21].C(OCC)(=O)C>C(OCC)(=O)C.C(OCC)C>[ClH:21].[F:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][CH2:9][NH:7][CH3:6])=[CH:12][C:13]=1[O:18][CH3:19]

Komponenten

5

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 69413197[2-(4-Fluoro-3-methoxyphenyl)ethyl]methylcarbamic acid t-butyl ester

Produkt 1

HCID 21098553[2-(4-Fluoro-3-methoxyphenyl)ethyl]methylamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of [2-(4-fluoro-3-methoxyphenyl)ethyl]methylcarbamic acid t-butyl ester (506 mg) in ethyl acetate (2 mL) was added a solution of 4N hydrochloric acid-ethyl acetate (2 mL) at room temperature and allowed to stand for 2.5 hours. The resulting solid was diluted with diethyl ether, then filtered, and washed with diethyl ether. After drying by aeration, the title compound (338 mg) was obtained as a colorless solid.

Aufarbeitung

  1. filtrationfiltered
  2. washwashed with diethyl ether
  3. customAfter drying by aeration

Quellen und Nachweise

ORD-Eintrag
ord-6aa24a190bbb48b5a545aa134e129106
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07217723B2

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