Triethylamine → 5-(4-Methylpiperazin-1-yl)-2-nitroaniline

HRID 13520

Reaktionsgleichung

Reaktionsgleichung von HRID 13520
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.CN1C(=O)CCC1.C(N(CC)CC)C.F[C:23]1[CH:24]=[CH:25][C:26]([N+:30]([O-:32])=[O:31])=[C:27]([NH2:29])[CH:28]=1>O>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:23]2[CH:24]=[CH:25][C:26]([N+:30]([O-:32])=[O:31])=[C:27]([NH2:29])[CH:28]=2)[CH2:4][CH2:3]1

Komponenten

6

Edukt 4

HCID 8471TriethylamineHCID 13387N-methyl-2-pyrrolidoneHCID 531671-MethylpiperazineHCID 753995-Fluoro-2-nitroaniline

Produkt 1

HCID 27600345-(4-Methylpiperazin-1-yl)-2-nitroaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of N-methylpiperazine (1.0 eq), NMP, triethylamine (3.0 eq) and 5-fluoro-2-nitrophenylamine (1.0 eq) were heated at 90° C. for 1 hours. The reaction was allowed to cool to room temperature and then poured into water and let stand for 12 hours. The resulting solid was collected and dried and utilized without further purification. MH+=237.3.

Aufarbeitung

  1. customThe resulting solid was collected
  2. customdried
  3. customutilized without further purification

Quellen und Nachweise

ORD-Eintrag
ord-912e0e0b843a42cba63f5551c1645ee6
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728010B2

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