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1h-Benzimidazole-1-carboxylic acid,4-(azidomethyl)-,1,1-dimethylethyl ester → 2-Chloro-4-[[[[1-[(1,1-dimethylethoxy)carbonyl]benzimidazol-4-yl]methyl]amino]carbonyl]benzoic acid, methyl ester

HRID 1352034
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Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1352034
[N:1]([CH2:4][C:5]1[C:13]2[N:12]=[CH:11][N:10]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[C:9]=2[CH:8]=[CH:7][CH:6]=1)=[N+]=[N-].[Cl:21][C:22]1[CH:23]=[C:24]([CH:35]=[CH:36][C:37]=1[C:38]([O:40][CH3:41])=[O:39])[C:25](ON1C(=O)CCC1=O)=[O:26]>[Pd].CO.C1C=CC=CC=1>[Cl:21][C:22]1[CH:23]=[C:24]([C:25]([NH:1][CH2:4][C:5]2[C:13]3[N:12]=[CH:11][N:10]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[C:9]=3[CH:8]=[CH:7][CH:6]=2)=[O:26])[CH:35]=[CH:36][C:37]=1[C:38]([O:40][CH3:41])=[O:39]
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Komponenten

6

Edukt 2

HCID 207147611h-Benzimidazole-1-carboxylic acid,4-(azidomethyl)-,1,1-dimethylethyl esterHCID 235607681-[[3-Chloro-4-(methoxycarbonyl)benzoyl]oxy]-2,5-pyrrolidinedione

Produkt 1

HCID 865851472-Chloro-4-[[[[1-[(1,1-dimethylethoxy)carbonyl]benzimidazol-4-yl]methyl]amino]carbonyl]benzoic acid, methyl esterAusbeute 66,3 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysator
HCID 241BenzeneLösungsmittel
HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 4-(azidomethyl)benzimidazole-1-carboxylic acid, 1,1-dimethylethyl ester (Example 13; 1.40, 5.1 mmol), 1-[[3-chloro-4-(methoxycarbonyl)benzoyl]oxy]-2,5-pyrrolidinedione (Example 5; 1.62 g, 5.2 mmol), and 10% palladium on charcoal (210 mg) in methanol (40 mL) and benzene (2 mL) was hydrogenated at atmospheric pressure for 105 min and then filtered through Celite. TIc indicated that the reaction was not complete so more 10% palladium on charcoal (210 mg) was added and the mixture was hydrogenated at atmospheric pressure for 3 h and then shaken at 50 psi of hydrogen for 3 h. The reaction mixture was allowed to stand under hydrogen for 12 h, then filtered through Celite, evaporated, and chromatographed (20–100% ethyl acetate/hexanes) to give 2-chloro-4-[[[[1-[(1,1-dimethylethoxy)carbonyl]benzimidazol-4-yl]methyl]amino]carbonyl]benzoic acid, methyl ester (1.50 g, 66%). A solution of the ester (1.45 g, 3.3 mmol) in methanol (15 mL) and 3 M lithium hydroxide solution (5.5 mL) was stirred at room temperature overnight. A white solid was filtered off and discarded. The filtrate was evaporated to dryness. Water and 1 M HCl (16.6 mL) were added, and the mixture was filtered and washed with water to give 2-chloro-4-[[[(benzimidazol-4-yl)methyl]amino]carbonyl]-benzoic acid (925 mg, 86%).

Aufarbeitung

  1. filtrationfiltered through Celite
  2. additionwas added
  3. waitthe mixture was hydrogenated at atmospheric pressure for 3 h
  4. waitto stand under hydrogen for 12 h
  5. filtrationfiltered through Celite
  6. customevaporated
  7. customchromatographed (20–100% ethyl acetate/hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-1efa91d6442b43869003b01d50c5ace7
Quelldatensatz
uspto-grants-2007_05
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US07217728B2

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