Ammonium Hydroxide → 2-Chloro-4-quinolineacetamide
Reaktionsgleichung
C[O:2][C:3](=O)[CH2:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([Cl:15])[CH:6]=1.[NH4+:17].[OH-]>>[Cl:15][C:7]1[CH:6]=[C:5]([CH2:4][C:3]([NH2:17])=[O:2])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1Komponenten
3
Versuchsvorschrift
used as starting material may be prepared as follows: a) 2-(2-chloro-quinolin-4-yl)-acetic acid methyl ester may be prepared as disclosed in EP-A1-0 364 327 and Indian J. Chem. 1994, 33B, 747–751. b) 2-(2-chloro-quinolin-4-yl)-acetic acid methyl ester (100 mg, 0.42 mmol) is suspended in 28% NH4OH (2.0 mL). The mixture is stirred at RT overnight. The solvent is evaporated to afford 2-(2-chloro-quinolin-4-yl)-acetamide as a solid.
Aufarbeitung
- custommay be prepared
- customThe solvent is evaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-97098ce4c73c41b88aeb8e4d725e634a