Water → Ethyl (2-formamido-5-chlorothiazol-4-yl)glyoxylate

HRID 13532

Reaktionsgleichung

Reaktionsgleichung von HRID 13532
[CH:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:8]=1)=[O:2].[Cl:16]N1C(=O)CCC1=O.O>CN(C=O)C>[CH:1]([NH:3][C:4]1[S:5][C:6]([Cl:16])=[C:7]([C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:8]=1)=[O:2]

Komponenten

5

Edukt 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 2733245Ethyl 2-(formylamino)-alpha-oxo-4-thiazoleacetate

Produkt 1

HCID 14326717Ethyl (2-formamido-5-chlorothiazol-4-yl)glyoxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Ethyl 2-(Formylaminothiazol-4-yl)-2-oxoacetate (9.1 g, 39.87 mmol) (obtained from Aldrich, Milwaukee, Wis.) was slurried in 50 mL of anhydrous DMF. N-Chlorosuccinimide (5.6 g, 41.86 mmol) was added as a solid and the suspension was stirred at room temperature. After 18 hours, the reaction mixture was poured into 500 mL of water. The resulting white precipitate was filtered, washed with water and air dried to afford the title intermediate as a white solid.

Aufarbeitung

  1. filtrationThe resulting white precipitate was filtered
  2. washwashed with water and air
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-572aaac4a1614a098cd42dd318d131d2
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728127B2

Verknüpfte Notizen

Wird geladen…