Sodium borohydride → Tert-butyl 2-hydroxy-2-(pyridin-3-yl)ethylcarbamate

HRID 1354403Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1354403
[O:1]=[C:2]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8].[BH4-].[Na+]>C(O)C>[OH:1][CH:2]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8]

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 58993194tert-Butyl (2-oxo-2-(pyridin-3-yl)ethyl)carbamate

Produkt 1

HCID 19351381Tert-butyl 2-hydroxy-2-(pyridin-3-yl)ethylcarbamateAusbeute 103 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of the product from step (b) (1.30 g) in ethanol (50 ml) was added sodium borohydride (105 mg). The mixture was stirred for 1.5 h then evaporated. Water was added and the mixture extracted twice with ethyl acetate. The combined organic layers were washed (brine) and dried (MgSO4). The solvent was evaporated off to give the sub-title compound (1.35 g) as an oil.

Aufarbeitung

  1. customthen evaporated
  2. additionWater was added
  3. extractionthe mixture extracted twice with ethyl acetate
  4. washThe combined organic layers were washed (brine)
  5. dry with materialdried (MgSO4)
  6. customThe solvent was evaporated off

Quellen und Nachweise

ORD-Eintrag
ord-822bfe8892a74c148d6c5ff5b093b398
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07223794B2

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