N-Methylethylenediamine → 2,2,2-trifluoro-N-[2-(methylamino)ethyl]acetamide

HRID 1356450Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1356450
[F:1][C:2]([F:9])([F:8])[C:3]([O:5]CC)=O.[CH3:10][NH:11][CH2:12][CH2:13][NH2:14]>C(OCC)C>[F:9][C:2]([F:1])([F:8])[C:3]([NH:14][CH2:13][CH2:12][NH:11][CH3:10])=[O:5]

Komponenten

4

Edukt 2

HCID 8014N-MethylethylenediamineHCID 9794Ethyl trifluoroacetate

Produkt 1

HCID 107022842,2,2-trifluoro-N-[2-(methylamino)ethyl]acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a solution of ethyl trifluoroacetate (10 ml) in diethyl ether (20 ml) in an ice bath was added dropwise N-methylethylenediamine (7.4ml) for one hr. After addition, the reaction mixture was warmed to room temperature and stirred for 2 hr. Removal of ethyl ether from the reaction mixture gave the titled compound (14 g).

Aufarbeitung

  1. additionAfter addition
  2. customRemoval of ethyl ether from the reaction mixture

Quellen und Nachweise

ORD-Eintrag
ord-0c90826f741147f39366c3d0d7efbf58
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06586475B1

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