Sodium Carbonate → 3'-(N-Cinnamyl-N-methylaminomethyl)acetophenone

HRID 1356824

Reaktionsgleichung

Reaktionsgleichung von HRID 1356824
[CH2:1]([NH:10][CH3:11])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.CC(C)(C)C#CC=CCNC.C(=O)([O-])[O-].[Na+].[Na+].C(=O)([O-])[O-].[K+].[K+].Br[CH2:36][C:37]1[CH:38]=[C:39]([C:43](=[O:45])[CH3:44])[CH:40]=[CH:41][CH:42]=1>>[CH2:1]([N:10]([CH2:36][C:37]1[CH:38]=[C:39]([C:43](=[O:45])[CH3:44])[CH:40]=[CH:41][CH:42]=1)[CH3:11])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Komponenten

6

Edukt 5

HCID 10340Sodium CarbonateHCID 11430Potassium CarbonateHCID 189183N-methyl-3-phenylprop-2-en-1-amineHCID 154798071-(3-(Bromomethyl)phenyl)ethan-1-oneHCID 53427009N,6,6-trimethylhept-2-en-4-yn-1-amine

Produkt 1

HCID 699361453'-(N-Cinnamyl-N-methylaminomethyl)acetophenoneAusbeute 49,5 %

Versuchsvorschrift

The procedure described in Example 1 was repeated, except that N-cinnamyl methylamine [instead of N-(6,6-dimethyl-2-hepten-4-ynyl)methylamine] (650 mg; 3.04 mmol), sodium carbonate (instead of potassium carbonate) (1.5 eq), and 3′-bromomethylacetophenone (1.5 eq) were used, to thereby yield 0.42 g of the target compound (yield: 49.5%).

Quellen und Nachweise

ORD-Eintrag
ord-d8416139524347bfac9c50fba1398f58
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06586633B1

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