Acetamide, N-ethyl-N-(4-nitrophenyl)- → Acetamide, N-(4-aminophenyl)-N-ethyl-

HRID 1356995Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1356995
[C:1]([N:4]([CH2:14][CH3:15])[C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1)(=[O:3])[CH3:2]>C1COCC1.[Pd]>[C:1]([N:4]([CH2:14][CH3:15])[C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 74583Acetamide, N-ethyl-N-(4-nitrophenyl)-

Produkt 1

HCID 74921Acetamide, N-(4-aminophenyl)-N-ethyl-

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

N-acetyl-N-ethyl-4-nitroaniline (9a) (1.8 g, 8.64 mmol) is hydrogenated in THF (30 ml), over 10%Pd on carbon (100 mg) for 1.5 hours. The catalyst is removed by filtration and the solvent removed evaporation. The product crystalises on standing in hexane, and following filtration, is dried under vacuum; ES+ (M+1) 178.88.

Aufarbeitung

  1. customfor 1.5 hours
  2. customThe catalyst is removed by filtration
  3. customthe solvent removed
  4. customevaporation
  5. customThe product crystalises
  6. filtrationfiltration
  7. customis dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-e61e8923ca8d4396b3db6ca9e2d5bab2
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06589950B1

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