Nitric Acid → HCID 54161804, Verbindung

HRID 1357856

Reaktionsgleichung

Reaktionsgleichung von HRID 1357856
[C:1]1([C@H:7]([CH3:12])[CH2:8][C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(=O)(=O)(O)O.[N+:18]([O-])([OH:20])=[O:19]>O>[N+:18]([C:4]1[CH:5]=[CH:6][C:1]([C@H:7]([CH3:12])[CH2:8][C:9]([OH:11])=[O:10])=[CH:2][CH:3]=1)([O-:20])=[O:19]

Komponenten

5

Edukt 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 852992(3R)-3-phenylbutanoic acid

Produkt 1

HCID 54161804HCID 54161804, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

(R)-3-phenylbutanoic acid (10.0 g) was added to concentrated sulphuric acid (40 mL) at −5° C. under nitrogen. The resulting thick gel-like mixture was stirred vigorously and fuming nitric acid (2.8 mL) was added slowly over 20 minutes. The reaction mixture was poured onto a mixture of ice and water (500 mL) and the resulting white precipitate was collected by filtration, then washed thoroughly with water, and then dried to give the title compound (10.1 g) as a white solid.

Aufarbeitung

  1. filtrationthe resulting white precipitate was collected by filtration
  2. washwashed thoroughly with water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9f4a8f80140440f19ca0f2accf3509d4
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06593354B2

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