Hydrochloric Acid → 6-(Aminomethyl)picolinic acid hydrochloride
Reaktionsgleichung
[C:1]([C:3]1[N:8]=[C:7]([C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=1)#[N:2].[ClH:12].[H][H]>C(O)C.[Pd]>[ClH:12].[NH2:2][CH2:1][C:3]1[N:8]=[C:7]([C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=1Komponenten
6
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
6-Cyano-pyridine-2-carboxylic acid (compound F2) (250 mg, 1.6 mmol) is dissolved in ethanol (100 mL), concentrated hydrochloric acid (1 mL) and Pd/C (150 mg) are added and the mixture is hydrogenated at 3 bar hydrogen pressure for 6 h. The catalyst is filtered of and the crude product is transferred to the next step without any purification.
Aufarbeitung
- filtrationThe catalyst is filtered of and the crude product
- customis transferred to the next step without any purification
Quellen und Nachweise
- ORD-Eintrag
- ord-14864f76feee44109c49919adfc17e23
- Quelldatensatz
- uspto-grants-2011_02
- Patentnummer
- US07879853B2
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