1,4-Dibromobutane → HCID 23160672, Verbindung

HRID 1360397Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1360397
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1.Br[CH2:14][CH2:15][CH2:16][CH2:17]Br.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[N:1]1([C:2]2[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:6][CH:7]=2)[CH2:17][CH2:16][CH2:15][CH2:14]1

Komponenten

5

Edukt 3

HCID 80561,4-DibromobutaneHCID 11430Potassium CarbonateHCID 2761030Methyl 2-(4-aminophenyl)acetate

Produkt 1

HCID 23160672HCID 23160672, VerbindungAusbeute 24,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Methyl 4-aminophenylacetate (0.4 g, 2.4 mmol), 1,4-dibromobutane (0.29 mL, 2.4 mmol) and potassium carbonate (0.34 g, 2.6 mmol) were dissolved in dimethylformamide (30 mL), and the mixture was stirred overnight at 80° C. The solvent was evaporated, and the residue was worked up according to a conventional method and purified by silica gel column chromatography to give the title compound (0.13 g, 0.59 mmol).

Aufarbeitung

  1. customThe solvent was evaporated
  2. custompurified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-22e24d29648a4978bb12c9986712b8c0
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07879863B2

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